Bioinformatics Analysis of Mutations Sheds Light on the Evolution of Dengue NS1 Protein With Implications in the Identification of Potential Functional and Druggable Sites.

Sharma, Abhishek; Krishna, Sudhir; Sowdhamini, Ramanathan

Sharma, Abhishek; Krishna, Sudhir; Sowdhamini, Ramanathan.

Affiliation

Sharma A; National Centre for Biological Science, TIFR, Bangalore, India.
Krishna S; National Centre for Biological Science, TIFR, Bangalore, India.
Sowdhamini R; Department of School of Interdisciplinary Life Sciences, Indian Institute of Technology Goa, Farmagudi, Pond-403401, Goa, India.

Mol Biol Evol ; 40(3)2023 03 04.

Article in En | MEDLINE | ID: mdl-36795614

Subject(s)

Dengue; Mutation; Computational Biology; Viral Nonstructural Proteins/genetics

Key words

NS1 protein; antiviral drug screening; compensatory mutations; molecular evolution; protein stability; proteinprotein interaction motifs; single versus combination of mutations; virtual saturation mutagenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dengue Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Mol Biol Evol Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: India

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