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De novo design of luciferases using deep learning.
Yeh, Andy Hsien-Wei; Norn, Christoffer; Kipnis, Yakov; Tischer, Doug; Pellock, Samuel J; Evans, Declan; Ma, Pengchen; Lee, Gyu Rie; Zhang, Jason Z; Anishchenko, Ivan; Coventry, Brian; Cao, Longxing; Dauparas, Justas; Halabiya, Samer; DeWitt, Michelle; Carter, Lauren; Houk, K N; Baker, David.
Affiliation
  • Yeh AH; Department of Biochemistry, University of Washington, Seattle, WA, USA. hsyeh@ucsc.edu.
  • Norn C; Institute for Protein Design, University of Washington, Seattle, WA, USA. hsyeh@ucsc.edu.
  • Kipnis Y; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA. hsyeh@ucsc.edu.
  • Tischer D; Department of Biochemistry, University of Washington, Seattle, WA, USA.
  • Pellock SJ; Institute for Protein Design, University of Washington, Seattle, WA, USA.
  • Evans D; Department of Biochemistry, University of Washington, Seattle, WA, USA.
  • Ma P; Institute for Protein Design, University of Washington, Seattle, WA, USA.
  • Lee GR; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
  • Zhang JZ; Department of Biochemistry, University of Washington, Seattle, WA, USA.
  • Anishchenko I; Institute for Protein Design, University of Washington, Seattle, WA, USA.
  • Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.
  • Cao L; Institute for Protein Design, University of Washington, Seattle, WA, USA.
  • Dauparas J; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
  • Halabiya S; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
  • DeWitt M; School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, China.
  • Carter L; Department of Biochemistry, University of Washington, Seattle, WA, USA.
  • Houk KN; Institute for Protein Design, University of Washington, Seattle, WA, USA.
  • Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Nature ; 614(7949): 774-780, 2023 02.
Article in En | MEDLINE | ID: mdl-36813896
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deep Learning / Luciferases Language: En Journal: Nature Year: 2023 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deep Learning / Luciferases Language: En Journal: Nature Year: 2023 Type: Article Affiliation country: United States