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Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function.
Laudette, Marion; Lindbom, Malin; Arif, Muhammad; Cinato, Mathieu; Ruiz, Mario; Doran, Stephen; Miljanovic, Azra; Rutberg, Mikael; Andersson, Linda; Klevstig, Martina; Henricsson, Marcus; Bergh, Per-Olof; Bollano, Entela; Aung, Nay; Gustav Smith, J; Pilon, Marc; Hyötyläinen, Tuulia; Oresic, Matej; Perkins, Rosie; Mardinoglu, Adil; Levin, Malin C; Borén, Jan.
Affiliation
  • Laudette M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Lindbom M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Arif M; Science for Life Laboratory, Royal Institute of Technology, Stockholm 17165, Sweden.
  • Cinato M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Ruiz M; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 40530, Sweden.
  • Doran S; Faculty of Dentistry, Oral & Craniofacial Sciences, Centre for Host-Microbiome Interactions, King's College London, London WC2R 2L2, UK.
  • Miljanovic A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Rutberg M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Andersson L; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Klevstig M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Henricsson M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Bergh PO; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Bollano E; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg 41345, Sweden.
  • Aung N; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
  • Gustav Smith J; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London SW15 5PN, UK.
  • Pilon M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health National Health Service Trust, West Smithfield EC1A 7BE, UK.
  • Hyötyläinen T; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
  • Oresic M; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg 41345, Sweden.
  • Perkins R; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 40530, Sweden.
  • Mardinoglu A; School of Natural Sciences and Technology, Örebro University, Örebro 70182, Sweden.
  • Levin MC; School of Medical Sciences, Örebro University, Örebro 70182, Sweden.
  • Borén J; Turku Bioscience Centre, University of Turku, Turku 20520, Finland.
Cardiovasc Res ; 119(7): 1537-1552, 2023 07 04.
Article in En | MEDLINE | ID: mdl-36880401
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Proprotein Convertase 9 Limits: Animals Language: En Journal: Cardiovasc Res Year: 2023 Type: Article Affiliation country: Sweden
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Proprotein Convertase 9 Limits: Animals Language: En Journal: Cardiovasc Res Year: 2023 Type: Article Affiliation country: Sweden