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Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework.
Mourtzi, Niki; Charisis, Sokratis; Tsapanou, Angeliki; Ntanasi, Eva; Hatzimanolis, Alexandros; Ramirez, Alfredo; Heilmann-Heimbach, Stefanie; Grenier-Boley, Benjamin; Lambert, Jean-Charles; Yannakoulia, Mary; Kosmidis, Mary; Dardiotis, Efthimios; Hadjigeorgiou, Georgiios; Sakka, Paraskevi; Georgakis, Marios; Yaakov, Stern; Scarmeas, Nikolaos.
Affiliation
  • Mourtzi N; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Charisis S; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Tsapanou A; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Ntanasi E; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Hatzimanolis A; Department of Neurology, The Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
  • Ramirez A; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Heilmann-Heimbach S; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
  • Grenier-Boley B; Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
  • Lambert JC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
  • Yannakoulia M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
  • Kosmidis M; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
  • Dardiotis E; Department of Psychiatry, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, Texas, USA.
  • Hadjigeorgiou G; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Sakka P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Georgakis M; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille, France.
  • Yaakov S; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille, France.
  • Scarmeas N; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Alzheimers Dement ; 19(9): 3794-3805, 2023 09.
Article in En | MEDLINE | ID: mdl-36895094
ABSTRACT

INTRODUCTION:

We constructed a polygenic risk score (PRS) for ß-amyloid (PRSAß42) to proxy AD pathology and investigated its association with incident Alzheimer's disease (AD)/amnestic mild cognitive impairment (aMCI) and the influence of cognitive reserve (CR), proxied by educational years, on the relationship between PRSAß42 and AD/aMCI risk.

METHODS:

A total of 618 cognitive-normal participants were followed-up for 2.92 years. The association of PRSAß42 and CR with AD/aMCI incidence was examined with COX models. Then we examined the additive interaction between PRSAß42 and CR and the CR effect across participants with different PRSAß42 levels.

RESULTS:

Higher PRSAß42 and CR were associated with a 33.9% higher risk and 8.3% less risk for AD/aMCI, respectively. An additive interaction between PRSAß42 and CR was observed. High CR was associated with 62.6% less risk of AD/aMCI incidence only in the high-PRSAß42 group.

DISCUSSION:

A super-additive effect of PRSAß42 and CR on AD/aMCI risk was observed. CR influence was evident in participants with high PRSAß42.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognitive Reserve / Alzheimer Disease / Cognitive Dysfunction / Amyloidosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Alzheimers Dement Year: 2023 Type: Article Affiliation country: Greece
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognitive Reserve / Alzheimer Disease / Cognitive Dysfunction / Amyloidosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Alzheimers Dement Year: 2023 Type: Article Affiliation country: Greece