Naringenin facilitates M2 macrophage polarization after myocardial ischemia-reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway.

Ma, Kuiying; Liu, Wenqing; Liu, Qi; Hu, Pengfei; Bai, Lingyu; Yu, Miao; Yang, Yan

Naringenin facilitates M2 macrophage polarization after myocardial ischemia-reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway.

Ma, Kuiying; Liu, Wenqing; Liu, Qi; Hu, Pengfei; Bai, Lingyu; Yu, Miao; Yang, Yan.

Affiliation

Ma K; Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Liu W; Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Liu Q; Emergency Department, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Hu P; Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Bai L; Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Yu M; Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.
Yang Y; Department of General Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao City, China.

Environ Toxicol ; 38(6): 1405-1419, 2023 Jun.

Article in En | MEDLINE | ID: mdl-36988289

Subject(s)

Flavanones; Inflammasomes; Myocardial Reperfusion Injury; Animals; Mice; Inflammasomes/metabolism; Macrophages; Myocardial Reperfusion Injury/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Transcription Factors/metabolism; Flavanones/pharmacology

Key words

M1 polarization; M2 polarization; NLRP3 inflammasome; Naringenin; TFEB; macrophage; myocardial ischemia-reperfusion injury; nuclear translocation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Flavanones / Inflammasomes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Environ Toxicol Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2023 Type: Article Affiliation country: China

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