Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na<sub>V</sub>1.7.

Wisedchaisri, Goragot; Gamal El-Din, Tamer M; Zheng, Ning; Catterall, William A

Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na_V1.7.

Wisedchaisri, Goragot; Gamal El-Din, Tamer M; Zheng, Ning; Catterall, William A.

Affiliation

Wisedchaisri G; Department of Pharmacology, University of Washington, Seattle, WA 98195.
Gamal El-Din TM; Department of Pharmacology, University of Washington, Seattle, WA 98195.
Zheng N; Department of Pharmacology, University of Washington, Seattle, WA 98195.
Catterall WA; HHMI, University of Washington, Seattle, WA 98195.

Proc Natl Acad Sci U S A ; 120(14): e2219624120, 2023 04 04.

Article in En | MEDLINE | ID: mdl-36996107

Subject(s)

Erythromelalgia; Voltage-Gated Sodium Channels; Humans; NAV1.7 Voltage-Gated Sodium Channel/genetics; NAV1.7 Voltage-Gated Sodium Channel/metabolism; Pain/genetics; Pain/metabolism; Mutation; Erythromelalgia/genetics; Erythromelalgia/metabolism; Erythromelalgia/pathology; Voltage-Gated Sodium Channels/genetics; Threonine/genetics

Key words

action potential; channelopathies; pain; sensory nerves; sodium channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Erythromelalgia / Voltage-Gated Sodium Channels Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Type: Article

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