Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway.

Wu, Qing; Zhao, Ming; Li, Dongling; He, Xi; Zang, Weijin

Wu, Qing; Zhao, Ming; Li, Dongling; He, Xi; Zang, Weijin.

Affiliation

Wu Q; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.
Zhao M; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.
Li D; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.
He X; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.
Zang W; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.

FASEB J ; 37(5): e22917, 2023 05.

Article in En | MEDLINE | ID: mdl-37039813

Subject(s)

Diabetes Mellitus; Diabetic Cardiomyopathies; Endotoxemia; Gastrointestinal Microbiome; Mice; Rats; Animals; Lipopolysaccharides/pharmacology; Extracellular Signal-Regulated MAP Kinases; Endotoxemia/drug therapy; Inflammation/metabolism; Anti-Inflammatory Agents/pharmacology; Acetylcholine/pharmacology; Cholinergic Agents; Bacteria; Glucose/pharmacology; Receptors, Cholinergic; Diabetes Mellitus/drug therapy

Key words

ERK/Egr-1 pathway; cholinergic drugs; diabetic myocardial injury; gut microbiota; lipopolysaccharide; metabolic inflammation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endotoxemia / Diabetes Mellitus / Diabetic Cardiomyopathies / Gastrointestinal Microbiome Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2023 Type: Article

Fulltext

XML

PubMed Links

Search on Google