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The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice.
Postmus, Andrea C; Kruit, Janine K; Eilers, Roos E; Havinga, Rick; Koster, Mirjam H; Johmura, Yoshikazu; Nakanishi, Makoto; van de Sluis, Bart; Jonker, Johan W.
Affiliation
  • Postmus AC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Kruit JK; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Eilers RE; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Havinga R; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Koster MH; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Johmura Y; Division of Cancer and Senescence Biology, Cancer Research Institute, Institute for Frontier Science Initiative, Kanazawa University, Kakuma, Kanazawa, Japan.
  • Nakanishi M; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • van de Sluis B; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Jonker JW; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: j.w.jonker@umcg.nl.
Toxicol Appl Pharmacol ; 468: 116531, 2023 06 01.
Article in En | MEDLINE | ID: mdl-37088304
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Cyclin-Dependent Kinase Inhibitor p16 Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2023 Type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Cyclin-Dependent Kinase Inhibitor p16 Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2023 Type: Article Affiliation country: Netherlands