Updates on Tumor Biology in Vestibular Schwannoma.
Otolaryngol Clin North Am
; 56(3): 421-434, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-37121611
ABSTRACT
Vestibular schwannomas (VSs) are benign tumors that develop after biallelic inactivation of the neurofibromatosis type 2 (NF2) gene that encodes the tumor suppressor merlin. Merlin inactivation leads to cell proliferation by dysregulation of receptor tyrosine kinase signaling and other intracellular pathways. In VS without NF2 mutations, dysregulation of non-NF2 genes can promote pathways favoring cell proliferation and tumorigenesis. The tumor microenvironment of VS consists of multiple cell types that influence VS tumor biology through complex intercellular networking and communications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuroma, Acoustic
/
Neurofibromatosis 2
Limits:
Humans
Language:
En
Journal:
Otolaryngol Clin North Am
Year:
2023
Type:
Article
Affiliation country:
United States