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Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects.
Li, Yanchen; Si, Ru; Wang, Jin; Hai, Ping; Zheng, Yongbiao; Zhang, Qingqing; Pan, Xiaoyan; Zhang, Jie.
Affiliation
  • Li Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Si R; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Wang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Hai P; NMPA Key Laboratory for Quality Control of Traditional Chinese and Tibetan Medicine, Qinghai Provincial Drug Inspection and Testing Institute, Xining 810016, China.
  • Zheng Y; NMPA Key Laboratory for Quality Control of Traditional Chinese and Tibetan Medicine, Qinghai Provincial Drug Inspection and Testing Institute, Xining 810016, China.
  • Zhang Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Pan X; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
  • Zhang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: zhj8623@mail.xjtu.edu.cn.
Bioorg Chem ; 137: 106575, 2023 08.
Article in En | MEDLINE | ID: mdl-37148706
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Immunoconjugates / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Bioorg Chem Year: 2023 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Immunoconjugates / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Bioorg Chem Year: 2023 Type: Article Affiliation country: China