Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats.

Javed, Maira; Saleem, Ammara; Akhtar, Muhammad Furqan

Javed, Maira; Saleem, Ammara; Akhtar, Muhammad Furqan.

Affiliation

Javed M; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Saleem A; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Pakistan. ammarasaleem@gcuf.edu.pk.
Akhtar MF; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, 54000, Pakistan. furqan.pharmacist@gmail.com.

Inflammopharmacology ; 31(4): 1951-1966, 2023 Aug.

Article in En | MEDLINE | ID: mdl-37188832

Subject(s)

Arthritis, Experimental; Diosgenin; Sapogenins; Rats; Humans; Animals; Cytokines/metabolism; Rats, Wistar; Sapogenins/adverse effects; Carrageenan/pharmacology; Arthritis, Experimental/metabolism; Methotrexate/therapeutic use; Anti-Inflammatory Agents/therapeutic use; Oxidative Stress; Edema/drug therapy; Biomarkers/metabolism; Diosgenin/pharmacology

Key words

Anti-oxidant; Arthritis; COX-2; Diosgenin; Methotrexate; Protein denaturation; TNF-α

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Sapogenins / Diosgenin Limits: Animals / Humans Language: En Journal: Inflammopharmacology Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2023 Type: Article Affiliation country: Pakistan

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