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A fluorescein-based fluorescent probe for fast detection of malondialdehyde and its imaging study.
Peng, Min; Du, Quan-Rong; Yao, Xue; Li, Chun-Ni; Tian, Yang; Peng, Yu; Wang, Ya-Wen.
Affiliation
  • Peng M; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Du QR; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Yao X; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Li CN; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Tian Y; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Peng Y; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
  • Wang YW; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
Org Biomol Chem ; 21(22): 4643-4647, 2023 06 07.
Article in En | MEDLINE | ID: mdl-37211990
ABSTRACT
A simple fluorescein derivative as a fluorescent probe was synthesized for the detection of malondialdehyde (MDA) through a synergistic reaction to achieve ring-opening of fluorescein and formation of a benzohydrazide derivative. It exhibited high sensitivity and selectivity for MDA detection. The probe could also detect MDA quickly (within 60 s) and visually via UV-vis and fluorescent modes. Moreover, this probe showed good performance in the imaging of MDA in living cells and bacteria.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes Type of study: Diagnostic_studies Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes Type of study: Diagnostic_studies Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article