Recent advances in the development of Rho kinase inhibitors (2015-2021).
Med Res Rev
; 44(1): 406-421, 2024 01.
Article
in En
| MEDLINE
| ID: mdl-37265266
ABSTRACT
Rho-associated coiled-coil kinases (ROCKs) are key downstream effectors of small GTPases. ROCK plays a central role in diverse cellular events with accumulating evidence supporting the concept that ROCK is important in tumor development and progression. Numerous ROCK inhibitors have been investigated for their therapeutic potential in the treatment of cancers. In this article, we review recent research progress on ROCK inhibitors, especially those with potential for the treatment of cancers, reported in the literature from 2015 to 2021. Most ROCK inhibitors show potent in vitro and in vivo antitumor activities and have potential in the treatment of cancers.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rho-Associated Kinases
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Med Res Rev
/
Med. res. rev
/
Medicinal research reviews
Year:
2024
Type:
Article
Affiliation country:
China