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Taurine deficiency as a driver of aging.
Singh, Parminder; Gollapalli, Kishore; Mangiola, Stefano; Schranner, Daniela; Yusuf, Mohd Aslam; Chamoli, Manish; Shi, Sting L; Lopes Bastos, Bruno; Nair, Tripti; Riermeier, Annett; Vayndorf, Elena M; Wu, Judy Z; Nilakhe, Aishwarya; Nguyen, Christina Q; Muir, Michael; Kiflezghi, Michael G; Foulger, Anna; Junker, Alex; Devine, Jack; Sharan, Kunal; Chinta, Shankar J; Rajput, Swati; Rane, Anand; Baumert, Philipp; Schönfelder, Martin; Iavarone, Francescopaolo; di Lorenzo, Giorgia; Kumari, Swati; Gupta, Alka; Sarkar, Rajesh; Khyriem, Costerwell; Chawla, Amanpreet S; Sharma, Ankur; Sarper, Nazan; Chattopadhyay, Naibedya; Biswal, Bichitra K; Settembre, Carmine; Nagarajan, Perumal; Targoff, Kimara L; Picard, Martin; Gupta, Sarika; Velagapudi, Vidya; Papenfuss, Anthony T; Kaya, Alaattin; Ferreira, Miguel Godinho; Kennedy, Brian K; Andersen, Julie K; Lithgow, Gordon J; Ali, Abdullah Mahmood; Mukhopadhyay, Arnab.
Affiliation
  • Singh P; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Gollapalli K; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Mangiola S; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Schranner D; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.
  • Yusuf MA; School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.
  • Chamoli M; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
  • Shi SL; Exercise Biology Group, Technical University of Munich, Munich, Germany.
  • Lopes Bastos B; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
  • Nair T; Department of Bioengineering, Integral University, Lucknow, India.
  • Riermeier A; Buck Institute for Research on Aging, Novato, CA, USA.
  • Vayndorf EM; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Wu JZ; Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.
  • Nilakhe A; Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India.
  • Nguyen CQ; Exercise Biology Group, Technical University of Munich, Munich, Germany.
  • Muir M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Kiflezghi MG; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Foulger A; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Junker A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Devine J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Sharan K; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
  • Chinta SJ; Buck Institute for Research on Aging, Novato, CA, USA.
  • Rajput S; Department of Neurology, Columbia University, New York, NY, USA.
  • Rane A; Department of Neurology, Columbia University, New York, NY, USA.
  • Baumert P; Mouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK.
  • Schönfelder M; Buck Institute for Research on Aging, Novato, CA, USA.
  • Iavarone F; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
  • di Lorenzo G; Buck Institute for Research on Aging, Novato, CA, USA.
  • Kumari S; Exercise Biology Group, Technical University of Munich, Munich, Germany.
  • Gupta A; Exercise Biology Group, Technical University of Munich, Munich, Germany.
  • Sarkar R; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
  • Khyriem C; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
  • Chawla AS; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Sharma A; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Sarper N; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Chattopadhyay N; Harry Perkins Institute of Medical Research, Perth, WA, Australia.
  • Biswal BK; Curtin Medical School, Curtin University, Perth, WA, Australia.
  • Settembre C; Immunobiology Laboratory, National Institute of Immunology, New Delhi, India.
  • Nagarajan P; MRC-Protein Phosphorylation and Ubiquitination Unit, University of Dundee, Dundee, UK.
  • Targoff KL; Harry Perkins Institute of Medical Research, Perth, WA, Australia.
  • Picard M; Curtin Medical School, Curtin University, Perth, WA, Australia.
  • Gupta S; Pediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey.
  • Velagapudi V; Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.
  • Papenfuss AT; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
  • Kaya A; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
  • Ferreira MG; Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
  • Kennedy BK; Primate Research Facility, National Institute of Immunology, New Delhi, India.
  • Andersen JK; Small Animal Research Facility, National Institute of Immunology, New Delhi, India.
  • Lithgow GJ; Division of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.
  • Ali AM; Department of Neurology, Columbia University, New York, NY, USA.
  • Mukhopadhyay A; Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.
Science ; 380(6649): eabn9257, 2023 06 09.
Article in En | MEDLINE | ID: mdl-37289866
ABSTRACT
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taurine / Aging Limits: Animals / Humans Language: En Journal: Science Year: 2023 Type: Article Affiliation country: India
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taurine / Aging Limits: Animals / Humans Language: En Journal: Science Year: 2023 Type: Article Affiliation country: India