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The left atrial appendage closure by surgery-2 (LAACS-2) trial protocol rationale and design of a randomized multicenter trial investigating if left atrial appendage closure prevents stroke in patients undergoing open-heart surgery irrespective of preoperative atrial fibrillation status and stroke risk.
Madsen, Christoffer Læssøe; Park-Hansen, Jesper; Irmukhamedov, Akhmadjon; Carranza, Christian Lildal; Rafiq, Sulman; Rodriguez-Lecoq, Rafael; Palmer-Camino, Neiser; Modrau, Ivy Susanne; Hansson, Emma C; Jeppsson, Anders; Hadad, Rakin; Moya-Mitjans, Angel; Greve, Anders Møller; Christensen, Robin; Carstensen, Helle Gervig; Høst, Nis Baun; Dixen, Ulrik; Torp-Pedersen, Christian; Køber, Lars; Gögenur, Ismail; Truelsen, Thomas Clement; Kruuse, Christina; Sajadieh, Ahmad; Domínguez, Helena.
Affiliation
  • Madsen CL; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark.
  • Park-Hansen J; Department of Cardiology, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark.
  • Irmukhamedov A; Department of Heart, Lung, and Vascular Surgery, Odense University Hospital, Odense, Denmark.
  • Carranza CL; Department of Cardio-Thoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Rafiq S; Department of Cardio-Thoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Rodriguez-Lecoq R; Department of Cardiac Surgery, Hospital Vall d'Hebron, Barcelona, Spain.
  • Palmer-Camino N; Department of Cardiac Surgery, Hospital Vall d'Hebron, Barcelona, Spain.
  • Modrau IS; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Hansson EC; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Jeppsson A; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Hadad R; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.
  • Moya-Mitjans A; Department of Cardiology, Hospital Vall d'Hebron, Barcelona, Spain.
  • Greve AM; Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Christensen R; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Research, Research Unit of Rheumatology, University of Southern Denmark, Odense University Hospital, Denmark.
  • Carstensen HG; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.
  • Høst NB; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.
  • Dixen U; Department of Cardiology, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark.
  • Torp-Pedersen C; Department of Cardiology, Copenhagen University Hospital, North Zealand, Hilleroed, Denmark.
  • Køber L; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Gögenur I; Department of Surgery, Zealand University Hospital, Køge, Denmark.
  • Truelsen TC; Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Kruuse C; Department of Neurology, Neurovascular Research Unit, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
  • Sajadieh A; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.
  • Domínguez H; Department of Cardiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark. Electronic address: maria.helena.dominguez.vall-lamora.02@regionh.dk.
Am Heart J ; 264: 133-142, 2023 10.
Article in En | MEDLINE | ID: mdl-37302738
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atrial Fibrillation / Atrial Appendage / Stroke / Cardiac Surgical Procedures Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies Limits: Humans Language: En Journal: Am Heart J Year: 2023 Type: Article Affiliation country: Denmark
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atrial Fibrillation / Atrial Appendage / Stroke / Cardiac Surgical Procedures Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies Limits: Humans Language: En Journal: Am Heart J Year: 2023 Type: Article Affiliation country: Denmark