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Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration.
Li, Yini; Dou, Xiaoyang; Liu, Jun; Xiao, Yu; Zhang, Zhe; Hayes, Lindsey; Wu, Rong; Fu, Xiujuan; Ye, Yingzhi; Yang, Bing; Ostrow, Lyle W; He, Chuan; Sun, Shuying.
Affiliation
  • Li Y; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Dou X; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Liu J; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
  • Xiao Y; Howard Hughes Medical Institute, Chicago, IL, USA.
  • Zhang Z; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
  • Hayes L; Howard Hughes Medical Institute, Chicago, IL, USA.
  • Wu R; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Fu X; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
  • Ye Y; Howard Hughes Medical Institute, Chicago, IL, USA.
  • Yang B; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Ostrow LW; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • He C; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Sun S; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nat Neurosci ; 26(8): 1328-1338, 2023 08.
Article in En | MEDLINE | ID: mdl-37365312
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2023 Type: Article Affiliation country: United States