Acute-on-chronic liver failure: far to go-a review.
Crit Care
; 27(1): 259, 2023 07 01.
Article
in En
| MEDLINE
| ID: mdl-37393351
ABSTRACT
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term mortality. Heterogeneous definitions and diagnostic criteria for the clinical condition have been proposed in different geographic regions due to the differences in aetiologies and precipitating events. Several predictive and prognostic scores have been developed and validated to guide clinical management. The specific pathophysiology of ACLF remains uncertain and is mainly associated with an intense systemic inflammatory response and immune-metabolism disorder based on current evidence. For ACLF patients, standardization of the treatment paradigm is required for different disease stages that may provide targeted treatment strategies for individual needs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acute-On-Chronic Liver Failure
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Crit Care
Year:
2023
Type:
Article
Affiliation country:
China