MALAT1/miR-185-5p mediated high glucose-induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway.

Wang, Ting; Li, Na; Yuan, Lingling; Zhao, Mengnan; Li, Guizhi; Chen, Yanxia; Zhou, Hong

Wang, Ting; Li, Na; Yuan, Lingling; Zhao, Mengnan; Li, Guizhi; Chen, Yanxia; Zhou, Hong.

Affiliation

Wang T; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Li N; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Yuan L; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Zhao M; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Li G; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Chen Y; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Zhou H; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

J Cell Mol Med ; 27(17): 2495-2506, 2023 09.

Article in En | MEDLINE | ID: mdl-37395157

Subject(s)

MicroRNAs; RNA, Long Noncoding; Mice; Animals; Myocytes, Cardiac/metabolism; RNA, Long Noncoding/genetics; RNA, Long Noncoding/metabolism; MicroRNAs/genetics; MicroRNAs/metabolism; Apoptosis/genetics; Oxidative Stress; Glucose/toxicity; Glucose/metabolism; Mitochondria/metabolism

Key words

MALAT1; RhoA; cardiomyocyte apoptosis; diabetic cardiomyopathy; miR-185-5p; mitochondrial dynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / RNA, Long Noncoding Limits: Animals Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article

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