Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.

Young, R N; Bélanger, P; Champion, E; DeHaven, R N; Denis, D; Ford-Hutchinson, A W; Fortin, R; Frenette, R; Gauthier, J Y; Gillard, J

Young, R N; Bélanger, P; Champion, E; DeHaven, R N; Denis, D; Ford-Hutchinson, A W; Fortin, R; Frenette, R; Gauthier, J Y; Gillard, J.

J Med Chem ; 29(9): 1573-6, 1986 Sep.

Article in En | MEDLINE | ID: mdl-3746809

Subject(s)

Phenylbutyrates/pharmacology; SRS-A/antagonists & inhibitors; Animals; Biological Assay; Bronchi/physiology; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum/physiology; Muscle Contraction/drug effects; Phenylbutyrates/chemical synthesis; Trachea/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / SRS-A Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1986 Type: Article

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