Inflammasomes as regulators of non-infectious disease.
Semin Immunol
; 69: 101815, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37506489
ABSTRACT
Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components and highlight characteristics that permit inflammasome regulation of physiologic processes. We focus on emerging data that highlight the importance of inflammasome proteins in the regulation of reproduction, development, and malignancy. A framework is proposed to contextualize these findings.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Noncommunicable Diseases
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Semin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2023
Type:
Article
Affiliation country:
United States