Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings.

Clark, Alexander P; Clerx, Michael; Wei, Siyu; Lei, Chon Lok; de Boer, Teun P; Mirams, Gary R; Christini, David J; Krogh-Madsen, Trine

Clark, Alexander P; Clerx, Michael; Wei, Siyu; Lei, Chon Lok; de Boer, Teun P; Mirams, Gary R; Christini, David J; Krogh-Madsen, Trine.

Affiliation

Clark AP; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Clerx M; Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, UK.
Wei S; Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Lei CL; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
de Boer TP; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China.
Mirams GR; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Christini DJ; Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, UK.
Krogh-Madsen T; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

Europace ; 25(9)2023 08 02.

Article in En | MEDLINE | ID: mdl-37552789

Subject(s)

Induced Pluripotent Stem Cells; Myocytes, Cardiac; Humans; Action Potentials; Arrhythmias, Cardiac; Stem Cells

Key words

Arrhythmias; Computer simulation; Induced pluripotent stem cells; Ion channels; Patch clamp

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Induced Pluripotent Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Europace Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2023 Type: Article Affiliation country: United States

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