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Atovaquone exposure and Pneumocystis jirovecii cytochrome b mutations: French data and review of the literature.
Bonnet, Pierre L; Hoffmann, Claire V; Le Nan, Nathan; Bellamy, Lorenn; Hoarau, Gautier; Flori, Pierre; Demar, Magalie; Argy, Nicolas; Morio, Florent; Le Gal, Solène; Nevez, Gilles.
Affiliation
  • Bonnet PL; Laboratory of Parasitology and Mycology, Brest University Hospital, 29609 Brest, France.
  • Hoffmann CV; Fungal Respiratory Infections Research Unit (FRI), University of Angers, University of Western Brittany, 29238 Brest, France.
  • Le Nan N; Fungal Respiratory Infections Research Unit (FRI), University of Angers, University of Western Brittany, 29238 Brest, France.
  • Bellamy L; Fungal Respiratory Infections Research Unit (FRI), University of Angers, University of Western Brittany, 29238 Brest, France.
  • Hoarau G; Clinical Data Center, Brest University Hospital, 29609 Brest, France.
  • Flori P; Ophthalmology Department, OPHTARA Network, Bicêtre Paris Saclay University Hospital, AP-HP, 94276 Le Kremlin-Bicêtre, France.
  • Demar M; Laboratory of Infectious Agents, Parasitology Section, GIMAP, Faculty of Medicine, 42055 Saint-Etienne, France.
  • Argy N; University Hospital Laboratory of Parasitology-Mycology, Cayenne Hospital Center, 97306 Cayenne, French Guiana.
  • Morio F; IRD, MERIT, University of Paris Cité, 75006 Paris, France.
  • Le Gal S; Laboratory of Parasitology and Medical Mycology, Nantes University Hospital, 44000 Nantes, France.
  • Nevez G; Laboratory of Parasitology and Mycology, Brest University Hospital, 29609 Brest, France.
Med Mycol ; 61(9)2023 Sep 04.
Article in En | MEDLINE | ID: mdl-37656874
The mutations C431T (Ala144Val) and C823T (Leu275Phe) at the cytochrome b (CYB) active site of Pneumocystis jirovecii are associated with patient prior exposure to atovaquone. Conversely, these mutations are incidental in the absence of exposure. Overall, the presence of P. jirovecii CYB mutants remains low in France.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumocystis carinii Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Med Mycol Journal subject: MEDICINA VETERINARIA / MICROBIOLOGIA Year: 2023 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumocystis carinii Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Med Mycol Journal subject: MEDICINA VETERINARIA / MICROBIOLOGIA Year: 2023 Type: Article Affiliation country: France