CDKL5-mediated developmental tuning of neuronal excitability and concomitant regulation of transcriptome.

Liao, Wenlin; Lee, Kun-Ze

Liao, Wenlin; Lee, Kun-Ze.

Affiliation

Liao W; Institute of Neuroscience, National Cheng-Chi University, Taipei 116, Taiwan.
Lee KZ; Research Center for Mind, Brain and Learning, National Cheng-Chi University, Taipei 116, Taiwan.

Hum Mol Genet ; 32(23): 3276-3298, 2023 Nov 17.

Article in En | MEDLINE | ID: mdl-37688574

Subject(s)

Drug Resistant Epilepsy; Epilepsy; Spasms, Infantile; Humans; Animals; Mice; Transcriptome/genetics; Spasms, Infantile/genetics; Spasms, Infantile/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Epilepsy/genetics; Prosencephalon/metabolism; Mice, Knockout

Key words

CDKL5 deficiency disorder (CDD); KCC2; RNA sequencing (RNA-seq); electroencephalography (EEG); neonatal epilepsy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spasms, Infantile / Epilepsy / Drug Resistant Epilepsy Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2023 Type: Article Affiliation country: Taiwan

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