Agomelatine improves memory and learning impairments in a rat model of LPS-induced neurotoxicity by modulating the ERK/SorLA/BDNF/TrkB pathway.

Abdelaziz, Mahmoud; Mohamed, Ahmed F; Zaki, Hala F; Gad, Sameh S

Abdelaziz, Mahmoud; Mohamed, Ahmed F; Zaki, Hala F; Gad, Sameh S.

Affiliation

Abdelaziz M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA University), Giza, Egypt.
Mohamed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo, 11562, Egypt. Ahmed.fathi@pharma.cu.edu.eg.
Zaki HF; Faculty of Pharmacy, King Salman International University (KSIU), 46612, Ras Sedr, South Sinai, Egypt. Ahmed.fathi@pharma.cu.edu.eg.
Gad SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo, 11562, Egypt.

Naunyn Schmiedebergs Arch Pharmacol ; 397(3): 1701-1714, 2024 03.

Article in En | MEDLINE | ID: mdl-37712973

Subject(s)

Learning Disabilities; Lipopolysaccharides; Rats; Animals; Lipopolysaccharides/toxicity; Brain-Derived Neurotrophic Factor/metabolism; Amyloid Precursor Protein Secretases/metabolism; Amyloid Precursor Protein Secretases/pharmacology; MAP Kinase Signaling System; Amyloid beta-Peptides/metabolism; Maze Learning; Aspartic Acid Endopeptidases/metabolism; Aspartic Acid Endopeptidases/pharmacology; Learning Disabilities/metabolism; Learning Disabilities/pathology; Hippocampus; Memory Disorders/chemically induced; Memory Disorders/drug therapy; Memory Disorders/metabolism

Key words

Agomelatine; Autophagy; BDNF; ERK ½; Neuroplasticity; SorLA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Learning Disabilities Type of study: Prognostic_studies Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2024 Type: Article Affiliation country: Egypt

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