Cell-specific genome-scale metabolic modeling of SARS-CoV-2-infected lung to identify antiviral enzymes.

Chen, Ke-Lin; Wang, Feng-Sheng

Chen, Ke-Lin; Wang, Feng-Sheng.

Affiliation

Chen KL; Department of Chemical Engineering, National Chung Cheng University, Chiayi, Taiwan.
Wang FS; Department of Chemical Engineering, National Chung Cheng University, Chiayi, Taiwan.

FEBS Open Bio ; 13(12): 2172-2186, 2023 12.

Article in En | MEDLINE | ID: mdl-37734920

Subject(s)

COVID-19; SARS-CoV-2; Humans; SARS-CoV-2/genetics; COVID-19/genetics; Dihydroorotate Dehydrogenase; Antiviral Agents/pharmacology; Lung; Lipids

Key words

antiviral target design; constraint-based model; fuzzy optimization; genome-scale metabolic model; hybrid differential evolution; multilevel optimization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: FEBS Open Bio Year: 2023 Type: Article Affiliation country: Taiwan

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