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Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion.
Beaudry, Annie; Jacques-Ricard, Simon; Darracq, Anaïs; Sgarioto, Nicolas; Garcia, Araceli; García, Teresita Rode; Lemieux, William; Béland, Kathie; Haddad, Elie; Cordeiro, Paulo; Duval, Michel; McGraw, Serge; Richer, Chantal; Caron, Maxime; Marois, François; St-Onge, Pascal; Sinnett, Daniel; Banquy, Xavier; Raynal, Noël J-M.
Affiliation
  • Beaudry A; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Jacques-Ricard S; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Darracq A; Département de Pharmacologie et de Physiologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
  • Sgarioto N; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Garcia A; Département de Pharmacologie et de Physiologie, Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
  • García TR; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Lemieux W; Faculté de Pharmacie, Université de Montréal, Montreal, QC, Canada.
  • Béland K; Faculté de Pharmacie, Université de Montréal, Montreal, QC, Canada.
  • Haddad E; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Cordeiro P; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Duval M; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • McGraw S; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Richer C; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Caron M; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Marois F; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • St-Onge P; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Sinnett D; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Banquy X; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
  • Raynal NJ; Sainte-Justine University Hospital Research Center, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.
Sci Rep ; 13(1): 16443, 2023 09 30.
Article in En | MEDLINE | ID: mdl-37777587
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disulfiram / Neuroblastoma Type of study: Etiology_studies Limits: Animals / Child / Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Canada
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disulfiram / Neuroblastoma Type of study: Etiology_studies Limits: Animals / Child / Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Canada