Influence of antiresorptive/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions.
Clin Oral Investig
; 27(11): 6657-6666, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37783801
ABSTRACT
OBJECTIVE:
To investigate the influence of various antiresorptive and antiangiogenic medications on the resolution of experimentally induced peri-implantitis lesions after different surgical treatment approaches. MATERIALS ANDMETHODS:
Forty-eight albino rats randomly received a dual application of the following medications (1) amino-bisphosphonate (zoledronate (Zo)) (n = 8), (2) RANKL inhibitor (denosumab (De)) (n = 8), (3) antiangiogenic (bevacizumab (Be)) (n = 8), (4) Zo + Be (n = 8), (5) De + Be (n = 8), or (6) no medication (control (Co)) (n = 8). Ligature-induced peri-implantitis lesions were established at 2 maxillary implants over 16 weeks. Afterward, animals were randomly treated either with open flap debridement (OFD) or reconstructive therapy (RT). Treatment procedures were followed by a 12-week healing period. The histological outcomes included residual defect length (DL); defect width (DW) at the bone crest (BC-DW); 25%, 50%, and 75% of the DL; and areas of inflammatory cell infiltrate (ICT). When present, areas of bone sequester (BS) were assessed considering the animal as a statistical unit.RESULTS:
A total of 21 animals were analyzed (Zo RT = 3, OFD = 1; De RT = 3, OFD = 2; Be OFD = 1; Zo + Be RT = 2, OFD = 2; Co RT = 3, OFD = 2). Implant loss rates were comparable among the experimental groups. Except for the 25% and 75% DW values that were significantly higher in the Zo + Be group compared to the Co group (p = 0.04 and p = 0.03, respectively), no significant differences were found among the experimental groups for the DL (lowest-Be 0.56 mm; highest-Co 1.05 mm), BC-DW (lowest-De 0.86 mm, highest-Co 1.07 mm), 50% DW (lowest-De 0.86 mm; highest-Be + Zo 1.29 mm), and ICT (lowest-Be 0.56 mm2; highest-Be + Zo 1.65 mm2). All groups, except for the Zo and Be following RT, showed presence of BS.CONCLUSIONS:
The present findings did not reveal a marked effect of various antiresorptive/antiangiogenic medications on the resolution of experimentally induced peri-implantitis lesions, regardless of the surgical approach employed (OFD and RT). CLINICAL RELEVANCE Resolution of peri-implantitis lesions may not be affected by the investigated antiresorptive/antiangiogenic medications.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dental Implants
/
Plastic Surgery Procedures
/
Peri-Implantitis
Limits:
Animals
Language:
En
Journal:
Clin Oral Investig
Journal subject:
ODONTOLOGIA
Year:
2023
Type:
Article
Affiliation country:
Germany