Relationship between inhibition of mitochondrial respiration by naphthoquinones, their antitumor activity, and their redox potential.

Pisani, D E; Elliott, A J; Hinman, D R; Aaronson, L M; Pardini, R S

Pisani, D E; Elliott, A J; Hinman, D R; Aaronson, L M; Pardini, R S.

Biochem Pharmacol ; 35(21): 3791-8, 1986 Nov 01.

Article in En | MEDLINE | ID: mdl-3778505

Subject(s)

Mitochondria, Heart/drug effects; Naphthoquinones/pharmacology; Animals; Cattle; Multienzyme Complexes/antagonists & inhibitors; Multienzyme Complexes/metabolism; NADH, NADPH Oxidoreductases/antagonists & inhibitors; NADH, NADPH Oxidoreductases/metabolism; Oxidation-Reduction; Oxidoreductases/antagonists & inhibitors; Oxidoreductases/metabolism; Oxygen Consumption/drug effects; Structure-Activity Relationship

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Naphthoquinones / Mitochondria, Heart Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1986 Type: Article

Search on Google

XML

PubMed Links