Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis.
Hum Genomics
; 17(1): 89, 2023 10 03.
Article
in En
| MEDLINE
| ID: mdl-37789450
ABSTRACT
OBJECTIVE:
Previous studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis.METHODS:
Independent genetic variants associated with different food intakes at a genome-wide significant level were selected from summary-level statistics of genome-wide association studies from the UK Biobank. The association of these instrumental variables with urolithiasis was studied in a cohort from FinnGen Consortium.RESULTS:
Among the 15 studied food intake exposures, tea intake (odds ratio [OR] = 0.433, 95% confidence interval [CI] = 0.281-0.667, p value = 1.470 × 10-4) and fresh fruit intake (OR = 0.358, 95% CI = 0.185-0.694, p value = 0.002) were found to significantly reduce the risk of the calculus of kidney and ureter. The association remained consistent in the sensitivity analyses. After adjusting for the effects of vitamin D and vitamin C, fresh fruit intake remained the reverse causal association with the calculus of kidney and ureter.CONCLUSIONS:
Genetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Calculi
/
Urolithiasis
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Hum Genomics
Journal subject:
GENETICA
Year:
2023
Type:
Article
Affiliation country:
China