Exogenous Transforming Growth Factor-ß1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size.

Redgrave, Rachael E; Singh, Esha; Tual-Chalot, Simon; Park, Catherine; Hall, Darroch; Bennaceur, Karim; Smyth, Danielle J; Maizels, Rick M; Spyridopoulos, Ioakim; Arthur, Helen M

Redgrave, Rachael E; Singh, Esha; Tual-Chalot, Simon; Park, Catherine; Hall, Darroch; Bennaceur, Karim; Smyth, Danielle J; Maizels, Rick M; Spyridopoulos, Ioakim; Arthur, Helen M.

Affiliation

Redgrave RE; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Singh E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Tual-Chalot S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Park C; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Hall D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Bennaceur K; Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Smyth DJ; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
Maizels RM; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
Spyridopoulos I; Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom.
Arthur HM; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom. Electronic address: helen.arthur@ncl.ac.uk.

Am J Pathol ; 194(4): 562-573, 2024 Apr.

Article in En | MEDLINE | ID: mdl-37832870

Subject(s)

Helminths; ST Elevation Myocardial Infarction; Animals; Humans; Mice; Cicatrix/metabolism; Helminths/metabolism; Myocardium/pathology; ST Elevation Myocardial Infarction/metabolism; ST Elevation Myocardial Infarction/pathology; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta1/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ST Elevation Myocardial Infarction / Helminths Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2024 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google