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Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease in relation to sputum smear results: a retrospective cohort study.
Jung, Junghee; Chong, Yong Pil; Lee, Hyun Joo; Shim, Tae Sun; Jo, Kyung-Wook.
Affiliation
  • Jung J; Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center , Seoul, South Korea.
  • Chong YP; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea.
  • Lee HJ; Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea.
  • Shim TS; Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea.
  • Jo K-W; Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea.
Antimicrob Agents Chemother ; 67(11): e0100323, 2023 11 15.
Article in En | MEDLINE | ID: mdl-37843254
ABSTRACT
This study retrospectively analyzed the treatment outcomes of 110 patients with non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease who received intermittent or daily treatment with a three-drug oral antibiotic regimen (i.e., a macrolide, ethambutol, and rifampin) at a tertiary referral center in South Korea. Among these patients, 36 had sputum smear positivity. Of these 36 patients, intermittent treatment led to a lower culture conversion rate than daily treatment [50.0% (8/16) vs 85.0% (17/20), P = 0.034].
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchiectasis / Mycobacterium avium-intracellulare Infection / Lung Diseases Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2023 Type: Article Affiliation country: South Korea
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchiectasis / Mycobacterium avium-intracellulare Infection / Lung Diseases Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2023 Type: Article Affiliation country: South Korea