Exploration of antiproliferative potential of modified triazole-benzohydrazone scaffold: Multitarget approach.

Ali, Alaa M; Khalaf, Mohamed A; Bhongade, Bhoomendra A; Selim, Khalid B; Mostafa, Amany S

Ali, Alaa M; Khalaf, Mohamed A; Bhongade, Bhoomendra A; Selim, Khalid B; Mostafa, Amany S.

Affiliation

Ali AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Khalaf MA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Bhongade BA; Chemistry Department, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
Selim KB; Department of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
Mostafa AS; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Arch Pharm (Weinheim) ; 357(2): e2300383, 2024 Feb.

Article in En | MEDLINE | ID: mdl-37946599

Subject(s)

Antineoplastic Agents; Triiodobenzoic Acids; Vascular Endothelial Growth Factor Receptor-2; Humans; Structure-Activity Relationship; Molecular Docking Simulation; Cell Line, Tumor; Triazoles/pharmacology; Triazoles/chemistry; Phosphatidylinositol 3-Kinases/metabolism; Vascular Endothelial Growth Factor A/pharmacology; Cell Proliferation; Drug Screening Assays, Antitumor; Antineoplastic Agents/chemistry; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/chemistry; Molecular Structure

Key words

VEGFR-2; antiproliferative; c-Met; triazole; tyrosine kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triiodobenzoic Acids / Vascular Endothelial Growth Factor Receptor-2 / Antineoplastic Agents Limits: Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2024 Type: Article Affiliation country: Egypt

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