The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials.

Zorman, Masa; Hrast Rambaher, Martina; Kokot, Maja; Minovski, Nikola; Anderluh, Marko

Zorman, Masa; Hrast Rambaher, Martina; Kokot, Maja; Minovski, Nikola; Anderluh, Marko.

Affiliation

Zorman M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia.
Hrast Rambaher M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, Ljubljana 1000, Slovenia.
Kokot M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia.
Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia. Electronic address: nikola.minovski@ki.si.
Anderluh M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva Cesta 7, Ljubljana 1000, Slovenia. Electronic address: marko.anderluh@ffa.uni-lj.si.

Eur J Pharm Sci ; 192: 106632, 2024 Jan 01.

Article in En | MEDLINE | ID: mdl-37949194

Subject(s)

Methicillin-Resistant Staphylococcus aureus; Topoisomerase Inhibitors; Mice; Animals; Topoisomerase Inhibitors/pharmacology; Topoisomerase Inhibitors/therapeutic use; Topoisomerase Inhibitors/chemistry; Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/therapeutic use; Anti-Bacterial Agents/chemistry; DNA Gyrase/chemistry; DNA Gyrase/pharmacology; Zebrafish; Gram-Positive Bacteria; Gram-Negative Bacteria; Microbial Sensitivity Tests; Topoisomerase II Inhibitors/pharmacology; Topoisomerase II Inhibitors/therapeutic use

Key words

Bacterial resistance; DNA gyrase; Novel bacterial topoisomerase inhibitors (NBTIS); Topoisomerase IV; antibacterials

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methicillin-Resistant Staphylococcus aureus / Topoisomerase Inhibitors Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2024 Type: Article Affiliation country: Slovenia

Fulltext

XML

PubMed Links

Search on Google