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Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability.
Feng, Yang; Lee, Jaewon; Yang, Liping; Hilton, Mary Beth; Morris, Karen; Seaman, Steven; Edupuganti, Veera V Shivaji R; Hsu, Kuo-Sheng; Dower, Christopher; Yu, Guojun; So, Daeho; Bajgain, Pradip; Zhu, Zhongyu; Dimitrov, Dimiter S; Patel, Nimit L; Robinson, Christina M; Difilippantonio, Simone; Dyba, Marzena; Corbel, Amanda; Basuli, Falguni; Swenson, Rolf E; Kalen, Joseph D; Suthe, Sreedhar Reddy; Hussain, Myer; Italia, James S; Souders, Colby A; Gao, Ling; Schnermann, Martin J; St Croix, Brad.
Affiliation
  • Feng Y; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Lee J; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Yang L; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Hilton MB; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA; Basic Research Program, Frederick National Laboratory for Cancer Research (FNLCR), Leidos Biomedical Resear
  • Morris K; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA; Basic Research Program, Frederick National Laboratory for Cancer Research (FNLCR), Leidos Biomedical Resear
  • Seaman S; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Edupuganti VVSR; Organic Synthesis Section, Chemical Biology Laboratory, CCR, NCI, Frederick, MD 21702, USA.
  • Hsu KS; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Dower C; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Yu G; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • So D; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Bajgain P; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA.
  • Zhu Z; Protein Interactions Section, Cancer and Inflammation Program, NCI, NIH, Frederick, MD 21702, USA.
  • Dimitrov DS; Protein Interactions Section, Cancer and Inflammation Program, NCI, NIH, Frederick, MD 21702, USA.
  • Patel NL; Small Animal Imaging Program, FNLCR, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
  • Robinson CM; Animal Research Technical Support, FNLCR, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
  • Difilippantonio S; Animal Research Technical Support, FNLCR, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
  • Dyba M; Biophysics Resource in the Center for Structural Biology, NCI, NIH, Frederick, MD, USA.
  • Corbel A; Invention Development Program, Technology Transfer Center, NCI, Frederick, MD 21701, USA.
  • Basuli F; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, NIH, Rockville, MD 20850, USA.
  • Swenson RE; Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, NIH, Rockville, MD 20850, USA.
  • Kalen JD; Small Animal Imaging Program, FNLCR, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
  • Suthe SR; BrickBio, Woburn, MA 01801, USA.
  • Hussain M; BrickBio, Woburn, MA 01801, USA.
  • Italia JS; BrickBio, Woburn, MA 01801, USA.
  • Souders CA; BrickBio, Woburn, MA 01801, USA.
  • Gao L; Veterans Affairs Long Beach Healthcare System, Long Beach, CA 90822, USA.
  • Schnermann MJ; Organic Synthesis Section, Chemical Biology Laboratory, CCR, NCI, Frederick, MD 21702, USA.
  • St Croix B; Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD 21702, USA. Electronic address: stcroixb@mail.nih.gov.
Cell Rep ; 42(12): 113503, 2023 12 26.
Article in En | MEDLINE | ID: mdl-38019654
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoconjugates / Neoplasms Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2023 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoconjugates / Neoplasms Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2023 Type: Article Affiliation country: United States