Optimization of a cardiomyocyte model illuminates role of increased <i>I</i><sub>Na,L</sub> in repolarization reserve.

Fullerton, Kristin E; Clark, Alexander P; Krogh-Madsen, Trine; Christini, David J

Optimization of a cardiomyocyte model illuminates role of increased I_Na,L in repolarization reserve.

Fullerton, Kristin E; Clark, Alexander P; Krogh-Madsen, Trine; Christini, David J.

Affiliation

Fullerton KE; Physiology, Biophysics and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, New York, United States.
Clark AP; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, United States.
Krogh-Madsen T; Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States.
Christini DJ; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, United States.

Am J Physiol Heart Circ Physiol ; 326(2): H334-H345, 2024 Feb 01.

Article in En | MEDLINE | ID: mdl-38038718

Subject(s)

Arrhythmias, Cardiac; Myocytes, Cardiac; Adult; Humans; Myocytes, Cardiac/metabolism; Ion Channels; Heart Ventricles; Sodium/metabolism; Action Potentials

Key words

arrhythmias; late sodium current; repolarization reserve; systems biology; ventricular cardiomyocyte model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Myocytes, Cardiac Limits: Adult / Humans Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2024 Type: Article Affiliation country: United States

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