Microscopic Cracks Modulate Nucleation and Solid-State Crystallization Tendency of Amorphous Celecoxib.

Thakore, Samarth D; Das, Kaustav; Dalvi, Sameer V; Reddy, C Malla; Bansal, Arvind K

Thakore, Samarth D; Das, Kaustav; Dalvi, Sameer V; Reddy, C Malla; Bansal, Arvind K.

Affiliation

Thakore SD; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Mohali, Punjab 160062, India.
Das K; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Nadia, Kolkata ,West Bengal 741246, India.
Dalvi SV; Department of Chemical Engineering, Indian Institute of Technology-Gandhinagar,Palaj, Gujarat382355, India.
Reddy CM; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Nadia, Kolkata ,West Bengal 741246, India.
Bansal AK; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Mohali, Punjab 160062, India.

Mol Pharm ; 21(1): 76-86, 2024 Jan 01.

Article in En | MEDLINE | ID: mdl-38051598

Subject(s)

Water; Crystallization; Celecoxib/chemistry; Drug Stability; Phase Transition; Calorimetry, Differential Scanning; Solubility

Key words

amorphous; celecoxib; crack-induced crystallization; glass-forming ability; nanoindentation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2024 Type: Article Affiliation country: India

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