Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models.

Wang, Caixia; Li, Xuejing; Su, Jing; Duan, Jialiang; Yao, Yimin; Shang, Qingli

Wang, Caixia; Li, Xuejing; Su, Jing; Duan, Jialiang; Yao, Yimin; Shang, Qingli.

Affiliation

Wang C; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Li X; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Su J; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Duan J; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Yao Y; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Shang Q; Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. Electronic address: qinglishang@hb2h.com.

Exp Eye Res ; 238: 109751, 2024 01.

Article in En | MEDLINE | ID: mdl-38097101

Subject(s)

Choroidal Neovascularization; Endothelial Cells; Mice; Animals; Humans; Endothelial Cells/metabolism; Vascular Endothelial Growth Factor A/metabolism; Sincalide/metabolism; Choroidal Neovascularization/drug therapy; Choroidal Neovascularization/prevention & control; Choroidal Neovascularization/metabolism; Hypoxia/metabolism; Disease Models, Animal; Retinal Pigment Epithelium/metabolism

Key words

Cell proliferation; Choroidal neovascularization; Crocetin; Hypoxic injure; Vascular endothelial growth factor; mTORC1 signaling pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choroidal Neovascularization / Endothelial Cells Limits: Animals / Humans Language: En Journal: Exp Eye Res Year: 2024 Type: Article Affiliation country: China

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