Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques.
J Infect Dis
; 229(6): 1791-1795, 2024 Jun 14.
Article
in En
| MEDLINE
| ID: mdl-38134382
ABSTRACT
Vaginal inserts that can be used on demand before or after sex may be a desirable human immunodeficiency virus (HIV) prevention option for women. We recently showed that inserts containing tenofovir alafenamide fumarate (TAF, 20â
mg) and elvitegravir (EVG, 16â
mg) were highly protective against repeated simian/human immunodeficiency virus (SHIV) vaginal exposures when administered to macaques 4 hours before or after virus exposure (93% and 100%, respectively). Here, we show in the same macaque model that insert application 8 hours or 24 hours after exposure maintains high efficacy (94.4% and 77.2%, respectively). These data extend the protective window by TAF/EVG inserts and inform their clinical development for on-demand prophylaxis in women.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenine
/
Simian Acquired Immunodeficiency Syndrome
/
Quinolones
/
Anti-HIV Agents
/
Alanine
/
Tenofovir
Limits:
Animals
Language:
En
Journal:
J Infect Dis
/
J. infect. dis
/
Journal of infectious diseases
Year:
2024
Type:
Article
Affiliation country:
Georgia