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REEPing the harvest of reticulophagy and nucleophagy.
Zou, Chen-Xi; Du, Li-Lin.
Affiliation
  • Zou CX; National Institute of Biological Sciences, Beijing, China.
  • Du LL; College of Life Sciences, Beijing Normal University, Beijing, China.
Autophagy ; 20(5): 1197-1198, 2024 May.
Article in En | MEDLINE | ID: mdl-38163952
ABSTRACT
Under stress conditions, the endoplasmic reticulum and nucleus undergo turnover through selective macroautophagy/autophagy processes termed reticulophagy and nucleophagy, respectively. Our recent study has identified the protein Hva22/Rop1/Yep1, a member of the REEP1-REEP4 subfamily of the REEP protein family, as an essential factor for both processes in the fission yeast Schizosaccharomyces pombe. In the absence of Hva22/Yep1, reticulophagy and nucleophagy cargos without surrounding autophagic membranes accumulate in the cytoplasm. Interestingly, human proteins in the REEP1-REEP4 subfamily can functionally substitute for Hva22/Yep1 to facilitate reticulophagy. Phylogenetic and synteny analyses further reveal that the budding yeast reticulophagy receptor Atg40 is also a REEP1-REEP4 subfamily member. Similar to human REEP1-REEP4 subfamily proteins, Atg40 can functionally replace Hva22/Yep1. Based on our findings, we propose that promoting reticulophagy is a conserved function of REEP1-REEP4 subfamily proteins.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizosaccharomyces / Autophagy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Autophagy Year: 2024 Type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizosaccharomyces / Autophagy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Autophagy Year: 2024 Type: Article Affiliation country: China