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Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study.
Hegen, Harald; Berek, Klaus; Cavalla, Paola; Christiansen, Mikael; Emersic, Andreja; Di Filippo, Massimiliano; Gaetani, Lorenzo; Hassler, Michaela; Leurs, Cyra; Milosavljevic, Dejan; van Pesch, Vincent; Petersen, Thor; Presslauer, Stefan; Rosenstein, Igal; Rot, Uros; Schnabl, Christine; Teunissen, Charlotte; Vecchio, Domizia; Vercellino, Marco; Deisenhammer, Florian.
Affiliation
  • Hegen H; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Berek K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Cavalla P; Multiple Sclerosis Center and Neurologia I U, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
  • Christiansen M; Department of Clinical Biochemistry, Regional Hospital in Horsens, Horsens, Denmark.
  • Emersic A; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Di Filippo M; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
  • Gaetani L; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
  • Hassler M; FH Campus Wien, University of Applied Sciences, Vienna, Austria.
  • Leurs C; Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, Location VUMC, Amsterdam, Netherlands.
  • Milosavljevic D; FH Campus Wien, University of Applied Sciences, Vienna, Austria.
  • van Pesch V; Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium.
  • Petersen T; Sygehus Sønderjylland, Department of Regional Health Research, University Hospital of Southern Denmark, Hadersleben, Denmark.
  • Presslauer S; Department of Neurology, Klinikum Ottakring, Vienna, Austria.
  • Rosenstein I; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Rot U; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Schnabl C; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Teunissen C; FH Campus Wien, University of Applied Sciences, Vienna, Austria.
  • Vecchio D; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam UMC, Location Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands.
  • Vercellino M; Neurology Unit Department of Translational Medicine, Maggiore della Carità University Hospital, Novara, Italy.
  • Deisenhammer F; Multiple Sclerosis Center and Neurologia I U, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
Front Immunol ; 14: 1327947, 2023.
Article in En | MEDLINE | ID: mdl-38169789
ABSTRACT

Background:

Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).

Objective:

To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).

Methods:

Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.

Results:

A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.

Conclusion:

κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Sclerosis, Chronic Progressive / Multiple Sclerosis Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Front Immunol / Front. immunol / Frontiers in immunology Year: 2023 Type: Article Affiliation country: Austria
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Sclerosis, Chronic Progressive / Multiple Sclerosis Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Front Immunol / Front. immunol / Frontiers in immunology Year: 2023 Type: Article Affiliation country: Austria