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Brain energy metabolism: A roadmap for future research.
Rae, Caroline D; Baur, Joseph A; Borges, Karin; Dienel, Gerald; Díaz-García, Carlos Manlio; Douglass, Starlette R; Drew, Kelly; Duarte, João M N; Duran, Jordi; Kann, Oliver; Kristian, Tibor; Lee-Liu, Dasfne; Lindquist, Britta E; McNay, Ewan C; Robinson, Michael B; Rothman, Douglas L; Rowlands, Benjamin D; Ryan, Timothy A; Scafidi, Joseph; Scafidi, Susanna; Shuttleworth, C William; Swanson, Raymond A; Uruk, Gökhan; Vardjan, Nina; Zorec, Robert; McKenna, Mary C.
Affiliation
  • Rae CD; School of Psychology, The University of New South Wales, NSW 2052 & Neuroscience Research Australia, Randwick, New South Wales, Australia.
  • Baur JA; Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Borges K; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, QLD, Australia.
  • Dienel G; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Díaz-García CM; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
  • Douglass SR; Department of Biochemistry and Molecular Biology, Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Drew K; Behavioral Neuroscience, University at Albany, Albany, New York, USA.
  • Duarte JMN; Center for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
  • Duran J; Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, & Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.
  • Kann O; Institut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Barcelona, Spain.
  • Kristian T; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Lee-Liu D; Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120; Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg, Germany.
  • Lindquist BE; Veterans Affairs Maryland Health Center System, Baltimore, Maryland, USA.
  • McNay EC; Department of Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research (S.T.A.R.), University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Robinson MB; Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Región Metropolitana, Chile.
  • Rothman DL; Department of Neurology, Division of Neurocritical Care, Gladstone Institute of Neurological Disease, University of California at San Francisco, San Francisco, California, USA.
  • Rowlands BD; Behavioral Neuroscience, University at Albany, Albany, New York, USA.
  • Ryan TA; Departments of Pediatrics and System Pharmacology & Translational Therapeutics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Scafidi J; Magnetic Resonance Research Center and Departments of Radiology and Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
  • Scafidi S; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
  • Shuttleworth CW; Department of Biochemistry, Weill Cornell Medicine, New York, New York, USA.
  • Swanson RA; Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Uruk G; Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Vardjan N; Department of Neurosciences, University of New Mexico School of Medicine Albuquerque, Albuquerque, New Mexico, USA.
  • Zorec R; Department of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
  • McKenna MC; Department of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
J Neurochem ; 168(5): 910-954, 2024 05.
Article in En | MEDLINE | ID: mdl-38183680
ABSTRACT
Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Energy Metabolism Limits: Animals / Humans Language: En Journal: J Neurochem Year: 2024 Type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Energy Metabolism Limits: Animals / Humans Language: En Journal: J Neurochem Year: 2024 Type: Article Affiliation country: Australia