Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load.
Proc Biol Sci
; 291(2014): 20231273, 2024 Jan 10.
Article
in En
| MEDLINE
| ID: mdl-38196353
ABSTRACT
The relationship between pathogen proliferation and the cost of infection experienced by a host drives the ecology and evolution of host-pathogen dynamics. While environmental factors can shape this relationship, there is currently limited knowledge on the consequences of emerging contaminants, such as pharmaceutical pollutants, on the relationship between a pathogen's growth within the host and the damage it causes, termed its virulence. Here, we investigated how exposure to fluoxetine (Prozac), a commonly detected psychoactive pollutant, could alter this key relationship using the water flea Daphnia magna and its bacterial pathogen Pasteuria ramosa as a model system. Across a variety of fluoxetine concentrations, we found that fluoxetine shaped the damage a pathogen caused, such as the reduction in fecundity or intrinsic growth experienced by infected individuals, but with minimal change in average pathogen spore loads. Instead, fluoxetine modified the relationship between the degree of pathogen proliferation and its virulence, with both the strength of this trade-off and the component of host fitness most affected varying by fluoxetine concentration and host genotype. Our study underscores the potential for pharmaceutical pollution to modify the virulence of an invading pathogen, as well as the fundamental trade-off between host and pathogen fitness, even at the trace amounts increasingly found in natural waterways.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Infections
/
Environmental Pollutants
/
Daphnia magna
Type of study:
Health_economic_evaluation
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Proc Biol Sci
Journal subject:
BIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Australia