Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup.
Head Neck Pathol
; 18(1): 8, 2024 Feb 16.
Article
in En
| MEDLINE
| ID: mdl-38363429
ABSTRACT
Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular alterations are increasingly elucidated, testing for these features may not be readily available. In most cases, combinations of key morphologic features and diagnostic immunohistochemical markers can be used to replace molecular diagnostics. Conversely, some molecular alterations and expression of their surrogate biomarkers are not specific for any one entity, and it is important to recognize these to avoid diagnostic pitfalls. In this review, we discuss both old and new spindle cell tumors of the sinonasal tract, with an emphasis on histologic features and clinically relevant immunohistochemical markers serving as surrogate markers for underlying genomic alterations.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paranasal Sinuses
/
Sarcoma
/
Paranasal Sinus Neoplasms
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Head Neck Pathol
Journal subject:
NEOPLASIAS
/
PATOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Canada