Oxytocin and vasopressin signaling in health and disease.
Trends Biochem Sci
; 49(4): 361-377, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38418338
ABSTRACT
Neurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides that regulate many crucial physiological functions in vertebrates and invertebrates. The human neurohypophysial oxytocin/vasopressin (OT/VP) signaling system with its four receptors has become an attractive drug target for a variety of diseases, including cancer, pain, cardiovascular indications, and neurological disorders. Despite its promise, drug development faces hurdles, including signaling complexity, selectivity and off-target concerns, translational interspecies differences, and inefficient drug delivery. In this review we dive into the complexity of the OT/VP signaling system in health and disease, provide an overview of relevant pharmacological probes, and discuss the latest trends in therapeutic lead discovery and drug development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxytocin
/
Vasopressins
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Biochem Sci
/
Trends biochem. sci
/
Trends in biochemical sciences
Year:
2024
Type:
Article
Affiliation country:
Austria