Synthesis of pyrimido[4,5-b]quinolindiones and formylation: ultrasonically assisted reactions.
R Soc Open Sci
; 11(3): 231128, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38455992
ABSTRACT
Ultrasound-assisted synthesis of pyrimido|quinolindione derivatives via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from aminopyrimidinones, dimedone and aromatic aldehydes through a Mannich-type reaction sequence, and then functionalized under ultrasound irradiation and Vilsmeier-Haack conditions to give ß-chlorovinylaldehyde products. Ultrasonically assisted reactions, experimental simplicity, good yields without using metallic catalysts and the control of hazardous material release are features of this simple procedure.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
R Soc Open Sci
Year:
2024
Type:
Article
Affiliation country:
Colombia