Comparative evaluation of two different xenogenic acellular matrices on full-thickness skin wound healing.
J Wound Care
; 33(Sup3a): lxxiv-lxxx, 2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38457271
ABSTRACT
OBJECTIVE:
The purpose of the study was to compare the healing potential of bubaline small intestinal matrix (bSIM) and fish swim bladder matrix (FSBM) on full-thickness skin wounds in rabbits.METHOD:
Four full-thickness skin wounds (each 20×20mm) were created on the dorsum of 18 rabbits that were divided into three groups based on treatment untreated sham control (I), implanted with double layers of bSIM (II) and implanted with double layers of FSBM (III). Macroscopic, immunologic and histologic observations were made to evaluate wound healing.RESULTS:
Gross healing progression in the bSIM and FSBM groups showed significantly (p<0.05) less wound contraction compared with the sham group. The IgG concentration in rabbit sera was significantly (p<0.05) lower in the FSBM group compared with the bSIM group by enzyme-linked immunosorbent assay. The stimulation index of peripheral blood lymphocytes was significantly (p<0.05) lower in the FSBM group compared with the bSIM group by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Implantation of FSBM resulted in improved re-epithelialisation, neovascularisation and fibroplasia.CONCLUSION:
The FSBM is a more effective dermal substitute when compared with the bSIM for full-thickness skin wound repair in rabbit.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Soft Tissue Injuries
/
Acellular Dermis
Limits:
Animals
Language:
En
Journal:
J Wound Care
Journal subject:
ENFERMAGEM
Year:
2024
Type:
Article
Affiliation country:
India