Fatty acid oxidation drives mitochondrial hydrogen peroxide production by &#945;-ketoglutarate dehydrogenase.

Grayson, Cathryn; Faerman, Ben; Koufos, Olivia; Mailloux, Ryan J

Fatty acid oxidation drives mitochondrial hydrogen peroxide production by α-ketoglutarate dehydrogenase.

Grayson, Cathryn; Faerman, Ben; Koufos, Olivia; Mailloux, Ryan J.

Affiliation

Grayson C; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada.
Faerman B; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada.
Koufos O; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada.
Mailloux RJ; The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Quebec, Canada. Electronic address: ryan.mailloux@mcgill.ca.

J Biol Chem ; 300(4): 107159, 2024 Apr.

Article in En | MEDLINE | ID: mdl-38479602

Subject(s)

Fatty Acids; Hydrogen Peroxide; Ketoglutarate Dehydrogenase Complex; Mitochondria, Liver; Animals; Female; Male; Mice; Electron Transport Complex I/metabolism; Electron Transport Complex III/metabolism; Fatty Acids/metabolism; Hydrogen Peroxide/metabolism; Ketoglutarate Dehydrogenase Complex/metabolism; Mice, Inbred C57BL; Mitochondria, Liver/metabolism; Oxidation-Reduction

Key words

alpha-ketoglutarate dehydrogenase; fatty acid oxidation; hydrogen peroxide; mitochondria; oxidative eustress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Fatty Acids / Hydrogen Peroxide / Ketoglutarate Dehydrogenase Complex Limits: Animals Language: En Journal: J Biol Chem Year: 2024 Type: Article Affiliation country: Canada

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