Copper Nanodrugs by Atom Transfer Radical Polymerization.
Angew Chem Int Ed Engl
; 63(20): e202402747, 2024 05 13.
Article
in En
| MEDLINE
| ID: mdl-38488767
ABSTRACT
In this study, some copper catalysts used for atom transfer radical polymerization (ATRP) were explored as efficient anti-tumor agents. The aqueous solution of copper-containing nanoparticles with uniform spheric morphology was in situ prepared through a copper-catalyzed activator generated by electron transfer (AGET) ATRP in water. Nanoparticles were then directly injected into tumor-bearing mice for antitumor chemotherapy. The copper nanodrugs had prolonged blood circulation time and enhanced accumulation at tumor sites, thus showing potent antitumor activity. This work provides a novel strategy for precise and large-scale preparation of copper nanodrugs with high antitumor activity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Copper
/
Polymerization
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2024
Type:
Article
Affiliation country:
China