Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes.
J Int Med Res
; 52(3): 3000605241239034, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38546260
ABSTRACT
OBJECTIVES:
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (TRM). In the present study, we investigated potential functional genetic variations that may predispose MF development.METHODS:
A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to TRM function.RESULTS:
We included 21 patients and 19 healthy subjects in the study. Single nucleotide polymorphisms in the following genes were significantly more common in patients than in healthysubjects:
GZMB, HLA-DRB1, CD103, and NOTCH1. Moreover, the number of patients carrying single nucleotide polymorphisms in LAG3, NR4A2, and CD26L was significantly greater in the patient group than in the control group.CONCLUSIONS:
The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Mycosis Fungoides
Limits:
Humans
Language:
En
Journal:
J Int Med Res
Year:
2024
Type:
Article
Affiliation country:
Jordan