Many roads to a gene-environment interaction.
Am J Hum Genet
; 111(4): 626-635, 2024 04 04.
Article
in En
| MEDLINE
| ID: mdl-38579668
ABSTRACT
Despite the importance of gene-environment interactions (GxEs) in improving and operationalizing genetic discovery, interpretation of any GxEs that are discovered can be surprisingly difficult. There are many potential biological and statistical explanations for a statistically significant finding and, likewise, it is not always clear what can be claimed based on a null result. A better understanding of the possible underlying mechanisms leading to a detected GxE can help investigators decide which are and which are not relevant to their hypothesis. Here, we provide a detailed explanation of five "phenomena," or data-generating mechanisms, that can lead to nonzero interaction estimates, as well as a discussion of specific instances in which they might be relevant. We hope that, given this framework, investigators can design more targeted experiments and provide cleaner interpretations of the associated results.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene-Environment Interaction
Limits:
Humans
Language:
En
Journal:
Am J Hum Genet
Year:
2024
Type:
Article